| Pick # | NFL team | Player | Pos. | College |
| 1 | Cleveland Browns | Myles Garrett | DE | Texas A&M |
| 2 | San Francisco 49ers | Solomon Thomas | DE | Stanford |
| 3 | Chicago Bears | Jonathan Allen | DE | Alabama |
| 4 | Jacksonville Jaguars | Jamal Adams | S | LSU |
| 5 | Tennessee Titans | Mike Williams | WR | Clemson |
| 6 | New York Jets | Mitchell Trubisky | QB | North Carolina |
| 7 | Los Angeles Chargers | John Ross | WR | Washington |
| 8 | Carolina Panthers | Leonard Fournette | RB | LSU |
| 9 | Cincinnati Bengals | Reuben Foster | LB | Alabama |
| 10 | Buffalo Bills | O.J. Howard | TE | Alabama |
| 11 | New Orleans Saints | Marshon Lattimore | CB | Ohio State |
| 12 | Cleveland Browns | Malik Hooker | S | Ohio State |
| 13 | Arizona Cardinals | Corey Davis | WR | Western Michigan |
| 14 | Philadelphia Eagles | Christian McCaffrey | RB | Stanford |
| 15 | Indianapolis Colts | Derek Barnett | DE | Tennessee |
| 16 | Baltimore Ravens | Forrest Lamp | OL | Western Kentucky |
| 17 | Washington Redskins | Dalvin Cook | RB | Florida State |
| 18 | Tennessee Titans | Takkarist McKinley | LB | UCLA |
| 19 | Tampa Bay Buccaneers | David Njoku | TE | Miami |
| 20 | Denver Broncos | Cam Robinson | OL | Alabama |
| 21 | Detroit Lions | Charles Harris | DE | Missouri |
| 22 | Miami Dolphins | Garreon Conley | CB | Ohio State |
| 23 | New York Giants | Ryan Ramcyzk | OL | Wisconsin |
| 24 | Oakland Raiders | Sidney Jones | CB | Washington |
| 25 | Houston Texans | Deshaun Watson | QB | Clemson |
| 26 | Seattle Seahawks | Obi Melifonwu | S | UConn |
| 27 | Kansas City Chiefs | Pat Mahomes | QB | Texas Tech |
| 28 | Dallas Cowboys | Jabrill Peppers | DB | Michigan |
| 29 | Green Bay Packers | Tre’Davious White | DB | LSU |
| 30 | Pittsburgh Steelers | Marlon Humphrey | CB | Alabama |
| 31 | Atlanta Falcons | Taco Charlton | DE | Michigan |
| 32 | New Orleans Saints | Haason Reddick | DE | Temple |
ROUND 2
| Pick # | NFL team | Player | Pos. | College |
| 33 | Cleveland Browns | Deshone Kizer | QB | Notre Dame |
| 34 | San Francisco 49ers | Garrett Boles | OT | Utah |
| 35 | Jacksonville Jaguars | Malik McDowell | DT | Michigan State |
| 36 | Chicago Bears | Teez Tabor | CB | Florida |
| 37 | Los Angeles Rams | Tim Williams | LB | Alabama |
| 38 | Los Angeles Chargers | Carl Lawson | DE | Auburn |
| 39 | New York Jets | Kevin King | CB | Washington |
| 40 | Carolina Panthers | Budda Baker | FS | Washington |
| 41 | Cincinnati Bengals | Dion Dawkins | OG | Temple |
| 42 | New Orleans Saints | Dede Westbrook | WR | Oklahoma |
| 43 | Philadelphia Eagles | Quincy Wilson | CB | Florida |
| 44 | Buffalo Bills | Zay Jones | WR | East Carolina |
| 45 | Arizona Cardinals | Jarrad Davis | LB | Florida |
| 46 | Indianapolis Colts | Alvin Kamara | RB | Tennessee |
| 47 | Baltimore Ravens | T.J. Watt | OLB | Wisconsin |
| 48 | Minnesota Vikings | Taylor Moton | OT | Western Michigan |
| 49 | Washington Redskins | Raekwon McMillan | ILB | Ohio State |
| 50 | Tampa Bay Buccaneers | Josh Jones | S | North Carolina State |
| 51 | Denver Broncos | Evan Engram | TE | Ole Miss |
| 52 | Cleveland Browns | JuJu Smith-Shuster | WR | USC |
| 53 | Detroit Lions | Cooper Kupp | WR | Eastern Washington |
| 54 | Miami Dolphins | Zach Cunningham |
LB | Vandy |
| 55 | New York Giants | Zach Banner | OT | USC |
| 56 | Oakland Raiders | Larry Ogunjobi | DT | Charlotte |
| 57 | Houston Texans | Fabian Morieau | CB | UCLA |
| 58 | Seattle Seahawks | Chris Wormley | DT | Michigan |
| 59 | Kansas City Chiefs | Ryan Anderson | LB | Alabama |
| 60 | Dallas Cowboys | Adam Shaheen | TE | Ashland |
| 61 | Green Bay Packers | Desmond King | S | Iowa |
| 62 | Pittsburgh Steelers | Tyus Bowser | OLB | Houston |
| 63 | Atlanta Falcons | Dorian Johnson | OG | Pittsburgh |
| 64 | Carolina Panthers | Chris Godwin | WR | Penn State |
