Jacksonville Jaguars vs Indianapolis Colts | Week 17 Preview & Prediction

Trevor Lawrence, Liam Coen and the Jacksonville Jaguars take on Philip Rivers, Jonathan Taylor, Michael Pittman Jr., Shane Steichen and the Indianapolis Colts in a huge game in the AFC South with playoff implications, drawing significant attention from fans tracking pro football betting options ahead of kickoff.
The Daniel Jones injury and Sauce Gardner injury have been catastrophic to their chances of making a Super Bowl run, compounded by losing two first-round picks to the New York Jets in incredibly rich talent drafts in 2026 and 2027. The Jaguars can clinch the AFC South with a win and a Texans loss. Meanwhile, a loss by the Colts or a Texans win eliminates them from playoff contention.
Jacksonville has consistently beaten up on inferior opponents this year and has also handled very good teams like the Broncos and Chargers by double digits. They still have a realistic chance at the No. 1 seed, anchored by the league’s top-ranked rushing defense. Arik Armstead, Josh Hines-Allen and Travon Walker dominate the front line, while Foyesade Oluokun and Devin Lloyd clean things up behind them and defend the pass at a high level.
The Travis Hunter injury takes away speed and a versatile weapon on defense, but Brian Thomas Jr. has stepped up this season, along with Parker Washington and Jakobi Meyers. The Jaguars’ offense has also been fueled by the elusive Travis Etienne, who is putting together a stellar year in the backfield.
Laiatu Latu, J.T. Tuimoloau and the rest of the front 7 will need to get pressure on Lawrence consistently as the run game will be tough enough to stop. Josh Downs and Alec Pierce are very good weapons for Rivers as he looks to continue his good play. The Brayshul Tuten injury has taken off one of the faster running backs in the league but with Etienne playing great and Lawrence using his legs often, the run game has dangerous and it was in the upset win over the Broncos.
The Deforest Buckner injury has impacted one of the best defensive tackles in the league, they could not stop the 49ers a week ago which may make it very tough against the Liam Coen Jaguars who just dominated the Broncos. This will be a great game with huge stakes on the line at Lucas Oil Stadium, enjoy this Blitz With Blinder Video hosted by Josh Blinder.

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